Phloretin ic50 glut1
Webb1 maj 2009 · Phloretin (Ph), a natural product found in apples and pears with glucose transporter (GLUT) inhibitory activity, exerts antitumor effects. However, little is known … Webb30 juni 2024 · One well-studied effect of phloretin is the inhibition of glucose transporter 1 (GLUT1) and GLUT 2 [9,10,11]. It has been demonstrated that phloretin inhibits glucose transport across the bovine retinal pigment epithelium (RPE) by 45.5% and that it dose dependently prevents the formation of advanced glycation end products (AGEs) which …
Phloretin ic50 glut1
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Webb12 aug. 2006 · Immunostaining showed that GLUT1 was significantly increased in hypoxic regions of the human colon ... Inhibition of glucose uptake by phloretin sensitized cancer cells to DNR for its anticancer activity and apoptosis to overcome drug ... (IC50 = 50 nM, 44 nM in hypoxia vs. IC50 = 11 and 21 nM in normoxia in SW620 ... WebbA Biblioteca Virtual em Saúde é uma colecao de fontes de informacao científica e técnica em saúde organizada e armazenada em formato eletrônico nos países da Região Latino-Americana e do Caribe, acessíveis de forma universal na Internet de modo compatível com as bases internacionais.
WebbGLUT activity was partially inhibited by cytochalasin B (IC (50) = 0.44 +/- 0.1; K (i) = 0.3 +/- 0.1 microM) and phloretin (IC (50) = 8.7 microM) in AS-30D hepatocarcinoma. At physiological glucose, GLUT1 and GLUT3 were the predominant active isoforms in HeLa cells and AS-30D cells, respectively. WebbPhloretin alone or in combination with conventional chemotherapy, suppressed growth of xenograft tumors in nude mice (Chang et al., 2012; Choi, 2024). A major downside of …
Webb1 dec. 2003 · To confirm the specificity of the interaction mediated by GLUT, the cells were pretreated with phloretin, an inhibitor of GLUT-1, before adding RITC-labeled PVG polymer to the cell culture... Webb輸送は,GLUT2阻 害剤phloretinに より阻害され る, 現在,SGLT1は 糖吸収における一種のセンサー として働くとする仮説が提唱されている.すなわち, 食事などにより消化管の管 …
WebbWZB117 is an inhibitor of Glucose Transporter 1 (GLUT1). It inhibited cell proliferation in lung cancer A549 cells and breast cancer MCF7 cells with an IC50 of approximately 10 μM. CAS No. 1223397-11-2. Selleck's WZB117 has been cited by 10 Publications. Purity & Quality Control. Biological Activity ...
Webb21 sep. 2024 · The leading compound 6d, the IC50 of which with the GLUT1 inhibitor 4,6-oethylidene-α-D-glucose (EDG) and phloretin (31.80 µM and 38.71 µM) are 36 and 44 folds higher, respectively, than the 48 h IC50 (0.89 µM), ... For cytotoxicity assays, the GLUT1 inhibitors EDG (1) and phloretin (2), the OCT2 inhibitor Ctd. duxberry park elementary schoolWebbResults: The results showed that Phloretin inhibited the proliferation rate of the human SNU-1 gastric cancer cells and showed an IC50 of 18 µM. However, Phloretin showed … duxbury \u0026 hermansWebb7 dec. 2015 · Phloretin/Phlorizin, are very well know Glut1, SGLT1 and SGLT2 inhibitors. These are transporters responsible for transporting glucose into the the cells. For … dusk by herban cowboyWebbPhloretin has been used: to study its effect on the 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-d-glucose (2-NBDG) and 2-[N-(7-Nitrobenz-2-oxa-1,3-diazol-4-yl)amino] … duxborrow bridgewater maWebb1 jan. 2014 · We found that the GLUT1 inhibitors fasentin and phloretin increased the ROS levels induced by antimycin A and the superoxide generator pyrogallol. However, … duxburrow estates bridgewaterWebb26 jan. 2024 · Examining their specificity for GLUT1-5 revealed that the most potent GLUT3 inhibitor (G3iA, IC50 ~ 7 µM) was most selective for GLUT3, inhibiting less strongly only … duxbury advanced seriesWebb3 juni 2024 · The 2-deoxyglucose colorimetric assay showed that phloretin and siRNA silencing of GLUT1 decreased glucose uptake. However, unlike phloretin treatment, … duxborough massachusetts