Cisplatin and kidney

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August undefined, 2024

WebCisplatin has been a mainstay of cancer chemotherapy since the 1970s. Despite its broad anticancer potential, its clinical use has regularly been constrained by kidney toxicities. … WebFeb 16, 2016 · In cisplatin-based CCRT schedules, acute nephrotoxicity is commonly graded by an increase of serum creatinine levels, according to the Common Terminology Criteria for Adverse Events (CTCAE). Using these criteria nephrotoxicity ≥grade 3 occurs in only 4%–9% of patients [ 7, 10, 11 ].

Mechanisms of Cisplatin-Induced Acute Kidney Injury ... - PubMed

WebMar 13, 2024 · Background. Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe side effects, including nephrotoxicity and acute kidney injury (AKI) which develop due to renal accumulation and biotransformation of CDDP. WebMar 29, 2024 · Administration of the chemotherapeutic agent cisplatin leads to acute kidney injury (AKI). Cisplatin-induced AKI (CIAKI) has a complex pathophysiological map, which has been linked to cellular uptake and efflux, apoptosis, vascular injury, oxidative and endoplasmic reticulum stress, and inflammation … how to set indoor light timer

Cisplatin nephrotoxicity: new insights and therapeutic implications ...

WebCisplatin is a potent antineoplastic agent derived from platinum and commonly used in the treatment of head and ... both water restrictions and sodium supplementation may be appropriate when differentiating between diagnoses of renal salt wasting syndrome and syndrome of inappropriate antidiuretic hormone secretion. Fed Pract. 2024 December;38 ... WebMar 13, 2024 · Cisplatin (cis-diamminedichloroplatinum II, CDDP) is one of the most effective chemotherapeutic agents. However, its clinical use is limited due to the severe side effects, including nephrotoxicity and acute kidney injury (AKI) which develop due to renal accumulation and biotransformation of CDDP. WebRenal stem cell recovery systems, which can limit cisplatin-induced acute kidney injuries, appear to be at least partly dependent on TLR2 activation as well . Some studies have … note to self music video

Caspase 3/GSDME-dependent pyroptosis contributes to ... - Nature

Mitochondrial Superoxide Dismutase in Cisplatin-Induced Kidney …

WebMar 29, 2024 · A study involving TLR4-deficient mice administered a toxic dose of cisplatin (20 mg/kg) to induce acute renal failure within 72 h and reported significantly reduced markers of inflammation, nephrotoxicity, and renal function and decreased renal injury and histological abnormalities . WebMar 23, 2024 · Although optimization of dosing and inclusion of cisplatin as part of combination therapy has reduced the incidence of cisplatin-induced acute kidney injury (AKI), nephrotoxicity remains the dose-limiting side effect and is also associated with the risk of future chronic kidney disease (CKD) ( 2 ). how to set ink on fabricWebRenal injury induced by cisplatin primarily occurs in proximal tubules, 1 where the tubular injury causes a decrease in the glomerular filtration rate. 2 Because of this decrease in … note to self images

"WebTY - JOUR. T1 - Caught in the crossfire. T2 - cancer, cisplatin therapy, and kidney injury. AU - Humphreys, Benjamin D. PY - 2024/4/1. Y1 - 2024/4/1 " - Cisplatin and kidney

Cisplatin and kidney

Cisplatin nephrotoxicity: mechanisms and renoprotective …

WebAug 6, 2014 · Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and … WebThey check your levels of blood cells and other substances in the blood. They also check how well your liver and kidneys are working. What are the side effects of cisplatin? How often and how severe the side effects are can vary from person to person. They also depend on what other treatments you're having. When to contact your team

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WebFeb 15, 2024 · Traditional chemotherapeutic drugs, such as cisplatin and doxorubicin, are commonly used to treat various cancers, including lung, bladder, and ovarian cancer 1, 2, 3, 4. However, severe side... WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different diseases. Recently, it has been demonstrated that ABs from human renal proximal tubular HK-2 …

Webcisplatin (Rx) Brand and Other Names: Classes: Antineoplastics, Alkylating; Antineoplastics, Platinum Analog Print Dosing & Uses AdultPediatricGeriatric Dosage Forms & Strengths injectable... WebCisplatin (CP)-induced nephrotoxicity is widely accepted as a model for acute kidney injury (AKI). Although cisplatin-induced chronic kidney disease (CKD) in rodent has been reported, the role of phosphate in the cisplatin-induced CKD progression is not described.

WebTY - JOUR. T1 - Caught in the crossfire. T2 - cancer, cisplatin therapy, and kidney injury. AU - Humphreys, Benjamin D. PY - 2024/4/1. Y1 - 2024/4/1 WebRenal stem cell recovery systems, which can limit cisplatin-induced acute kidney injuries, appear to be at least partly dependent on TLR2 activation as well . Some studies have shown that depletion of TLR2 is associated with protection and subsequent reductions in pro-inflammatory IL-17A in CIN, and especially when there is simultaneous ...

WebFeb 16, 2024 · Cisplatin can affect your nervous system, increase your risk of bleeding or infection, or harm your kidneys. Call your doctor if you have a fever, mouth sores, cough, …

WebCisplatin has been a mainstay of cancer chemotherapy since the 1970s. Despite its broad anticancer potential, its clinical use has regularly been constrained by kidney … how to set individual error bars excelWebJan 1, 2024 · Cisplatin treatment induces premature senescence in renal tubular cells in vitro and in vivo To evaluate whether cisplatin can induce senescence in renal tubular cells in vitro, NRK cells were incubated with cisplatin (20 μg/ml) for 6 h, and then incubated in complete medium for 24, 48, and 72 h. note to self orenWebOct 13, 2024 · Cisplatin is nephrotoxin that can cause both acute kidney injury and chronic kidney disease. Accumulation of cisplatin in renal tubular cells induces various … note to self lyrics fftlWebCisplatin is one of the most widely used and most potent chemotherapy drugs. However, side effects in normal tissues and organs, notably nephrotoxicity in the kidneys, limit the … how to set initial timing on ford 302WebFeb 1, 2024 · Cisplatin may cause serious kidney problems. Tell you doctor right away if you have blood in urine, change in frequency of urination or amount of urine, difficulty in … note to self book by gayle kingWebSurgery-induced renal ischemia and reperfusion (I/R) injury and nephrotoxic drugs like cisplatin can cause acute kidney injury (AKI), for which there is no effective therapy. Lipid accumulation is evident following AKI in renal tubules although the mechanisms and pathological effects are unclear. Here, we report that Ehmt2-encoded histone ... how to set inkbird thermostatWebAug 24, 2024 · These renal injuries may cause delays and potentially cessation of cisplatin therapy and have long-term effects on renal function reserve. Thus, developing mechanism-based interventional strategies that minimize cisplatin-associated kidney injury without reducing efficacy would be of great benefit. note to self christian keyes